Biomedical and Health Sciences

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Subject Areas: Biomedical and Health Sciences (62)	29 Mar 2025

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The between-day reliability of fasted circulating irisin concentrations: a cohort study
FACETS • Vol. 10 • pp. 1 - 6
Irisin blood concentrations are investigated in many applied physiology studies, however between-day reliability is required for accurate interpretation, particularly in longitudinal interventions. Between-day reliability of irisin was calculated, and the influence of participant characteristics explored. Venous blood was sampled 24 h apart in 32 rested and fasted healthy adults (males n = 15, 19–80 years). Plasma irisin concentrations were measured using MILLIPLEX® xMAP immunoassay analysis (Merck KGaA, Darmstadt, Germany). Irisin reliability was analysed using coefficient of variation (CV) and intraclass correlation coefficients (ICCs). Regression analysis was used to explore the influence of participant characteristics. Overall, irisin was reliable between days (CV 12.7%, ICC r = 0.963, p < 0.001), with no influence of participant characteristics, when pre-sampling controls (intake, activity) were applied.
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Unraveling the link between birth order and blood pressure: insights from a comprehensive systematic review and meta-analysis
FACETS • Vol. 10 • pp. 1 - 8
The objective of the present systematic review was to incorporate previous studies investigating the association of birth order with the risk of systolic and diastolic blood pressure (DBP). We employed random-effects and Bayesian meta-analyses, complemented by subgroup and sensitivity analyses, including funnel plots, Begg's rank correlation test, Egger's linear regression test, Galbraith plots, and leave-one-out meta-analysis. Of the 13 articles analyzed, 92% (12 articles) were published from 2010 onwards. The aggregate sample comprised 466 853 firstborns and 646 786 later-born individuals. Geographically, the studies were primarily conducted in Europe (54%), followed by Asia (23%), and America (23%). The pooled mean difference for systolic blood pressure (SBP) under a random-effects model was 0.28 mm Hg (95% CI: −7.03 to 7.59), and for DBP was 0.33 mm Hg (95% CI: −5.38 to 6.04), neither of which reached statistical significance (SBP: Z = 0.08, P = 0.939; DBP: Z = 0.11, P = 0.910). Sensitivity analyses supported these findings. Bayesian meta-analysis presented a 95% credible interval for SBP and DBP ranging from −7.25 to 7.84 and −5.60 to 6.27, respectively. The investigation found no substantial evidence of a significant difference in SBP and DBP between firstborns and later-born individuals, challenging the hypothesis that birth order significantly impacts blood pressure levels. ID registration number: 567971.

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The between-day reliability of fasted circulating irisin concentrations: a cohort study

Unraveling the link between birth order and blood pressure: insights from a comprehensive systematic review and meta-analysis

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The between-day reliability of fasted circulating irisin concentrations: a cohort study

Unraveling the link between birth order and blood pressure: insights from a comprehensive systematic review and meta-analysis