CLOSE
Advanced searchCitation search
Suggested Terms:
Skip main navigation

Search Result

41 - 58of58
Refine Search
per page:
Relevance
Filters

You do not have any saved searches

  • OPEN ACCESS
    COVID-19 epidemiology in Canada from January to December 2020: the pre-vaccine era
    FACETS • Vol. 6 • pp. 760 - 822
    This paper summarizes COVID-19 disease epidemiology in Canada in the pre-vaccine era—from January through to December 2020. Canadian case numbers, risk factors, disease presentations (including severe and critical disease), and outcomes are described. Differences between provinces and territories in geography, population size and density, health demographics, and pandemic impact are highlighted. Key concepts in public health response and mitigation are reviewed, including masking, physical distancing, hand washing, and the promotion of outdoor interactions. Adequate investment in public health infrastructure is stressed, and regional differences in screening and testing strategies are highlighted. The spread of COVID-19 in Canadian workplaces, long-term care homes, and schools is described and lessons learned emphasized. The impact of COVID-19 on vulnerable populations in Canada—including Indigenous Peoples, ethnic minorities and newcomers, people who use drugs, people who are homeless, people who are incarcerated, and people with disabilities—is described. Sex and gender disparities are also highlighted. Author recommendations include strategies to reduce transmission (such as test–trace–isolate), the establishment of nationally standardized definitions and public reporting, the protection of high risk and vulnerable populations, and the development of a national strategy on vaccine allocation.
  • OPEN ACCESS
    Ensuring the success of data sharing in Canada
    FACETS • Vol. 6 • pp. 1534 - 1538
    The Canadian federal Tri-Agency Research Data Management Policy has recently been released. This will require Canadian universities and other research institutes to create and share strategic plans regarding data management and to equip their researchers with skills to complete data deposits. To help maximize the success of data sharing we outline five domains for research institutions to consider during implementation: training and education, paying for data sharing, audit and feedback, meta-science, and career advancement.
  • OPEN ACCESS
    Lower extremity muscle strength reference values for young Saudi male adults aged 21 to 23 years and their correlation with anthropometric parameters and balance
    FACETS • Vol. 7 • pp. 98 - 109
    Normative reference values for muscle strength are needed for muscle strength assessment and estimation of prognosis in lower extremity related neuromuscular disorders, as muscle strength influenced by anthropometric parameters and muscle strength itself affects balance. Normative reference values for muscle strength in the Saudi Arabian population is lacking in the literature. Hence, the current study aimed to establish normative reference values for lower extremity muscle strength and to correlate these values with anthropometric parameters and balance. Lower extremity muscle strength and balance were assessed by baseline hand-held dynamometer and by forward, lateral, and oblique direction reach tests in 421 young male adults between 21 and 23 years of age. The mean and standard deviation of lower extremity strength ranged from 43.83 ± 16.92 lb to 62.07 ± 10.74 lb. Body weight, body mass index, and oblique and lateral reach distances were correlated with some knee and ankle muscle strength values. Body weight, body mass index, and balance showed significant effect on lower extremity muscle strength. Furthermore, decreased muscle strength may impair balance; the current clinical practice should evaluate body weight, body mass index, and muscle strength during the assessment process.
  • OPEN ACCESS
    SARS-CoV-2 detection from the built environment and wastewater and its use for hospital surveillance
    FACETS • Vol. 7 • pp. 82 - 97
    Patients hospitalized with SARS-CoV-2 infections are major contributors to morbidity and mortality in health care settings. Our understanding of the distribution of this virus in the built health care environment and wastewater, and relationship to disease burden, is limited. We performed a prospective multi-center study of environmental sampling of SARS-CoV-2 from hospital surfaces and wastewater and evaluated their relationships with regional and hospital COVID-19 burden. We validated a qPCR-based approach to surface sampling and collected swab samples weekly from different locations and surfaces across two tertiary care hospital campuses for a 10-week period during the pandemic, along with wastewater samples. Over the 10-week period, 963 swab samples were collected and analyzed. We found 61 (6%) swabs positive for SARS-CoV-2, with the majority of these (n = 51) originating from floor samples. Wards that actively managed patients with COVID-19 had the highest frequency of positive samples. Detection frequency in built environment swabs was significantly associated with active cases in the hospital throughout the study. Wastewater viral signal changes appeared to predate change in case burden. Our results indicate that environment sampling for SARS-CoV-2, in particular from floors, may offer a unique and resolved approach to surveillance of COVID-19.
  • OPEN ACCESS
    Evaluation of a randomized nutrition intervention combining nutrition education and cooking workshops on dietary intakes and psychosocial determinants of performance in university football athletes
    FACETS • Vol. 7 • pp. 876 - 890
    Although nutrition influences performance, many athletes, including football players, do not meet nutritional requirements for their sport. The objective of this study was to determine the impact of a nutrition intervention combining nutrition education and cooking workshops on nutrition knowledge, intention, and perceived behavioral control in the preparation of healthy meals, dietary intakes, and diet quality in male university football players. Athletes (n = 23; age: 22 ± 1 year) were randomly assigned to an intervention (2 h/week) (n = 13) or control group (n = 10) over three weeks. Questionnaires were completed before (pre), immediately after (post 1), and two months after the intervention (post 2). Dietary intakes and diet quality were evaluated from three web-based 24-h dietary recalls per visit. Mixed linear models for repeated measures with Tukey’s post hoc test were performed to determine the effects of the intervention on all outcomes. There was a group by time interaction for nutrition knowledge (p = 0.002) that was higher immediately after and two months after the intervention compared to the control group. No differences on other outcomes were observed. Combining nutrition education and cooking workshops improved nutrition knowledge, but did not affect intention and perceived behavioral control in the preparation of healthy meals, dietary intakes, and diet quality in male university football athletes.
  • OPEN ACCESS
    Prior AICAR induces elevated glucose uptake concomitant with greater γ3-AMPK activation and reduced membrane cholesterol in skeletal muscle from 26-month-old rats
    FACETS • Vol. 7 • pp. 774 - 791
    Attenuated skeletal muscle glucose uptake (GU) has been observed with advancing age. It is important to elucidate the mechanisms linked to interventions that oppose this detrimental outcome. Earlier research using young rodents and (or) cultured myocytes reported that treatment with 5-aminoimidazole-4-carboxamide-1-β-d-ribofuranoside (AICAR; an AMP-activated protein kinase (AMPK) activator) can increase γ3-AMPK activity and reduce membrane cholesterol content, each of which has been proposed to elevate GU. However, the effect of AICAR treatment on γ3-AMPK activity and membrane cholesterol in skeletal muscle of aged animals has not been reported. Our purpose was to evaluate the effects of AICAR treatment on these potential mechanisms for enhanced glucose uptake in the skeletal muscle of aged animals. Epitrochlearis muscles from 26–27-month-old male rats were isolated and incubated ± AICAR, followed by 3 h incubation without AICAR, and then incubation with 3-O-methyl-[3 H] glucose (to assess GU ± insulin). Muscles were also analyzed for γ3-AMPK activity and membrane cholesterol content. Prior AICAR treatment led to increased γ3-AMPK activity, reduced membrane cholesterol content, and enhanced glucose uptake in skeletal muscle from aged rats. These observations revealed that two potential mechanisms for greater GU previously observed in younger animals and (or) cell models are also potentially relevant for enhanced GU by muscles from older animals.
  • OPEN ACCESS
    Changes in serum copeptin in the early onset of type 2 diabetes
    FACETS • Vol. 7 • pp. 1244 - 1257
    Copeptin (C-terminal fragment of pro-arginine vasopressin) levels change as fasting plasma glucose (FPG) and blood pressure change. To explore the clinical significance of changes in copeptin levels in development of type 2 diabetes mellitus (T2DM), we enrolled patients undergoing physical health examinations who met diagnostic criteria for prediabetes and T2DM. Subjects were divided into eight subgroups based on FPG levels and presence or absence of hypertension, including: a normal group (NGT), FPG < 5.6 mmol/L; prediabetes A, 5.6 mmol/L ≤ FPG < 6.1 mmol/L; prediabetes B, 6.1 mmol/L ≤ FPG < 7.0 mmol/L; and T2DM, FPG ≥ 7.0 mmol/L; participants were further into two subgroups by whether they had hypertension or not. Measures included biochemical indicators, fasting insulin (FINS), and copeptin. Copeptin levels in prediabetes A, prediabetes B, and T2DM groups increased significantly compared to NGT group (P < 0.01). No significant differences were found in copeptin levels between normal blood pressure and hypertension subgroups in all four groups. Copeptin levels correlated positively with systolic blood pressure, glycosylated hemoglobin (HbA1c), FPG, FINS, and insulin resistance index (HOMA-IR; P < 0.05–0.001), and negatively with insulin secretion index (P < 0.05–0.001). Stepwise regression analysis revealed that copeptin levels correlated independently with elevated HbA1c and aggravated HOMA-IR (P < 0.001). Increase in copeptin levels may aggravate insulin resistance, finally leading to T2DM.
  • OPEN ACCESS
    The association of typical and atypical symptoms with in-hospital mortality in older adults with COVID-19: a multicentre cohort study
    FACETS • Vol. 7 • pp. 1199 - 1213
    Atypical disease presentations are common in older adults with COVID-19. The objective of this study was to determine the prevalence of atypical and typical symptoms in older adults with COVID-19 through progressive pandemic waves and the association of these symptoms with in-hospital mortality. This retrospective cohort study included consecutive adults aged over 65 years with confirmed COVID-19 infection who were admitted to seven hospitals in Toronto, Canada, from 1 March 2020 to 30 June 2021. The median age for the 1786 patients was 78.0 years and 847 (47.5%) were female. Atypical symptoms (as defined by geriatric syndromes) occurred in 1187 patients (66.5%), but rarely occurred in the absence of other symptoms (n = 106; 6.2%). The most common atypical symptoms were anorexia (n = 598; 33.5%), weakness (n = 519; 23.9%), and delirium (n = 449; 25.1%). Dyspnea (adjusted odds ratio [aOR] 2.05; 95% confidence interval [CI] 1.62–2.62), tachycardia (aOR 1.87; 95% CI 1.14–3.04), and delirium (aOR 1.52; 95% CI 1.18–1.96) were independently associated with in-hospital mortality. In a cohort of older adults hospitalized with COVID-19 infection, atypical presentations frequently overlapped with typical symptoms. Further research should be directed at understanding the cause and clinical significance of atypical presentations in older adults.
  • OPEN ACCESS
    How not to manage a pandemic, and how to recover from it: Lessons from Ecuador
    FACETS • Vol. 7 • pp. 1367 - 1384
    Since the initial outbreak in December 2019, the COVID-19 pandemic has resulted in more than four million deaths worldwide. Ecuador initially experienced one of the worst coronavirus outbreaks in the world. The pandemic quickly overwhelmed health care systems resulting in excess deaths of 37 000 from March to October, 2020. The public health measures taken to stop the spread of the virus had a devastating impact on the economy. There was a sharp contraction (7.8%) in Ecuador’s GDP in 2020. Furthermore, income poverty and inequality increased dramatically. The lasting effects of the pandemic will be harder to overcome. This article recounts and analyzes the COVID-19 pandemic in Ecuador, to draw lessons from this complex experience, and from the benefit of limited but important successes. We also aim to provide suggestions for best practices moving forward.
  • OPEN ACCESS
    Funding change: An environmental scan of research funders’ knowledge translation strategic plans and initiatives across 10 high-income countries/regions
    FACETS • Vol. 8 • pp. 1 - 26
    Knowledge translation (KT) is the science and practice of dissemination and implementation of evidence. We describe how research funders operationalize and evaluate KT initiatives, identify challenges and opportunities, and suggest strategic considerations for KT support. We conducted an environmental scan, which included a systematic search of published and grey literature and a focus group with Canadian funders. A total of 130 published articles and 2415 grey literature sources were screened; 212 unique data sources were included. Published literature commonly described KT initiatives related to “KT practice and science funding.” These initiatives commonly provided funds for infrastructure development (e.g., clinical technologies, database subscriptions) to facilitate translational or applied research to address regional health priorities. Of the articles, 44% outlined an evaluation plan; few provided validated KT metrics. In the grey literature, 364 initiatives were described; the most commonly described initiatives related to “exchange and integrated KT.” Focus group participants hoped to see increased resources to support KT, exchange opportunities with policy/decision-makers, and evaluate KT initiatives. Funders completed various KT initiatives, which tended to engage stakeholders to set research priorities, collaborate with a range of stakeholders, build KT capacity, and mandate KT requirements. We provide six considerations for funders to support KT.
  • OPEN ACCESS
    The influence of sociodemographic and environmental factors on wildlife carcass submissions in urban areas: Opportunities for increasing equitable and representative wildlife health surveillance
    FACETS • Vol. 8 • pp. 1 - 13
    Wildlife health surveillance is important in rapidly expanding urban areas, where wildlife live in close association with humans and face unique health risks. Urban areas are not homogeneous, and social and environmental factors may affect the distribution of surveillance data we receive from these environments. The Canadian Wildlife Health Cooperative (CWHC) operates a national wildlife surveillance programme that receives carcass submissions for diagnostic evaluation. Our objective was to evaluate sociodemographic and environmental factors associated with CWHC submissions within two cities in Ontario, Canada. Submissions were mapped at two geographic scales and linked with census and environmental data. The results of mixed multivariable Poisson and negative binomial regression analyses suggest that natural (e.g., percent parkland) and anthropogenic environmental (e.g., presence of a zoo) and social variables (e.g., low income) are associated with submissions at both administratively relevant scales. Associations that are common across scales may represent robust intervention points and inform surveillance methodology/messaging. Surveillance data may influence public health policy, wildlife management, and other decision-making regarding the benefits/risks associated with coexistence with wildlife. This study highlights gaps in surveillance methodology that may prevent equal opportunity for participation in wildlife health surveillance and enable equal opportunity to benefit from the associated outputs.
  • OPEN ACCESS
    British Columbia freshwater salmon hatcheries demonstrate minimal contribution to piscine orthoreovirus (PRV) regional occurrence with no evidence for nonendemic strain introductions
    FACETS • Vol. 8 • pp. 1 - 9
    Piscine orthoreovirus genotype 1 (PRV-1) is a common virus in farmed and wild salmon in the northeastern Pacific Ocean. Its regional occurrence in freshwater is far less clear. From 2019 to 2021, tissues of 5619 juvenile anadromous salmon (primarily Atlantic, Chinook, and coho) sampled from 12 commercial and 27 enhancement British Columbia hatcheries during 83 sampling events were screened for PRV-1 prior to seawater entry. More than 2200 (∼40%) were also screened using a Pan-PRV assay targeting all known PRV genotypes. PRV-1 was detected in four coho salmon at two freshwater enhancement facilities and in one Chinook salmon at a commercial facility. Partial (S1 segment) genome sequencing identified detections to be of the PRV-1 subgenotype endemic to the northeastern Pacific. PRV-1 was not detected (5611 individuals; 99.9%) or test results were inconclusive (3 individuals; 0.05%) for all remaining samples screened for PRV-1. PRV-2 and PRV-3 were not detected using the Pan-PRV assay. It is concluded that commercial and enhancement freshwater hatcheries of British Columbia contribute minimally to the prevalence and persistence of PRV-1 in anadromous salmon of the northeastern Pacific, and these hatcheries appear not to have contracted or participated in the distribution of nonendemic forms of PRV in recent years.
  • OPEN ACCESS
    Potential impacts of reduced seafood consumption on myocardial infarction among coastal First Nations in British Columbia, Canada
    FACETS • Vol. 9 • pp. 1 - 13
    The objective of this study is to examine the potential cardiovascular risk of climate-related declines in seafood consumption among First Nations in British Columbia by assessing the combined effects of reduced omega-3 fatty acids and mercury intake from seafood on the risk of myocardial infarction (MI) in 2050 relative to 2009. The data were derived from the First Nations Food, Nutrition, and Environment Study. Seafood consumption among 369 randomly selected participants was estimated, and hair mercury concentrations were measured. Declines in seafood consumption were modelled based on previously projected climate change scenarios, and the associated changes in nutrients and contaminants were used to estimate the cardiovascular risk. Reduced seafood consumption was projected to increase the risk of MI by 4.5%–6.5% among older individuals (≥50 years), by 1.9%–2.6% in men, and by 1.3%–1.8% in women under lower and upper climate change scenarios, respectively. Reduced seafood consumption may have profound cardiovascular implications. Effective strategies are needed to promote sustainable seafood harvests and access to seafood for coastal First Nations.
  • OPEN ACCESS
    Prospective cohort study of Helicobacter pylori infection on the risk of nonalcoholic fatty liver disease
    FACETS • Vol. 9 • pp. 1 - 8
    To investigate the epidemiological connection between nonalcoholic fatty liver disease (NAFLD) and Helicobacter pylori (H. pylori). 6,478 retired and active workers, aged 22-69 years, were included in the study. Their baseline measures of height, weight, waist measurement, body mass index, blood pressure, fasting blood sugar, plasma lipid, liver function index, glycosylated hemoglobin, abdominal ultrasonography, and findings from the line “13 C urea breath test” H. pylori test were analyzed, and follow-up with consistent baseline methods and criteria was performed annually. Over a 4-year period, the prevalence of NAFLD increased by 16.9%, with 612 (18.7%) of those who tested positive for H. pylori developing NAFLD, whereas 484 (15.1%) of those who did not test positive for H. pylori were later diagnosed with new NAFLD (χ2 = 14.862, P < 0.05). One of the risk factors identified in the univariable Cox regression model for NAFLD was H. pylori (Hazard Ratio = 1.297; 95.0% confidence interval (CI) 1.150,1.485, P < 0.000); however, H. pylori continued to be an independent factor affecting the risk of NAFLD even after accounting for gender, age, and aspects of the metabolic syndrome (Hazard Ratio = 1.240; 95.0% CI 1.077,1.429, P = 0.003). The growth of NAFLD may be correlated with H. pylori infection.
  • OPEN ACCESS
    Youth COVID-19 stressors and associations with self-perceived health, depression, anxiety, and at-risk alcohol and cannabis use
    FACETS • Vol. 9 • pp. 1 - 10
    Adolescents and young adults have been particularly vulnerable to disruptions caused by the COVID-19 pandemic. The objectives were to identify youth's self-reported pandemic-related stressors and examine how these stressors were related to six negative health outcomes: self-perceived, fair-to-poor physical, and mental health, depression, anxiety, and at-risk alcohol and cannabis use. Data were from the Well-Being and Experiences Study (The WE Study) from Manitoba, Canada (17–22 years old; n = 587; collected from November 2021 to January 2022). The COVID-19 stressors reported most frequently since pandemic onset included: (1) not being able to spend time with friends (78.5%); (2) feeling lonely or isolated (69.9%); and (3) remote learning for school, college, or university (68.4%). In reference to the “past month”, frequently reported stressors were (1) remote learning (42.6%); (2) feeling lonely or isolated (41.2%); and (3) uncertainty about the future (41.1%). Overall, 26.1% of the sample perceived their physical health as fair-to-poor and 59.1% perceive their mental health as fair-to-poor. A number of stressors were related to fair-to-poor mental health, depression, and anxiety; fewer were related to fair-to-poor physical health and at-risk alcohol and cannabis use. These findings can inform future pandemics and recovery efforts to improve pandemic-related health risks among youth.
  • OPEN ACCESS
    Spatiotemporal patterns of low and highly pathogenic avian influenza virus prevalence in murres in Canada from 2007 to 2022—a case study for wildlife viral monitoring
    FACETS • Vol. 9 • pp. 1 - 13
    Migratory seabirds move across ocean basins and are one of the primary reservoirs of low pathogenic avian influenza virus (LPAIV). This includes the millions of thick-billed murres (Uria lomvia) and common murres (Uria aalge) that are distributed across northern hemisphere oceans. In response to increasingly frequent detections of highly pathogenic avian influenza virus (HPAIV) in Europe in 2020–2021, avian influenza virus (AIV) monitoring in wildlife has increased. We compiled data from murres tested for AIV in Canada between 2007 and 2022 to quantify spatiotemporal variation in the prevalence of LPAIV and HPAIV in these birds. No HPAIV was detected in murres prior to 2022, but HPAIV was present in 46% of both live/harvested and found dead murres in the northwestern Atlantic in 2022 with prevalence peaking at 63% among live birds in the summer. In the eastern Canadian Arctic, HPAIV prevalence in 2022 was <1% while LPAIV prevalence was 21%, which was significantly higher than previous sampling years. Power analyses suggest approximately 100 samples from breeding murres should be collected annually per colony or region to detect moderate changes in HPAIV prevalence. These analyses inform robust monitoring of viruses in wildlife, with implications for conservation, harvest management, and public health.
  • OPEN ACCESS
    Gender-based citation differences in speech–language pathology
    FACETS • Vol. 9 • pp. 1 - 8
    Gender inequalities are well documented in science and typically favor male scientists. A particularly pervasive gender difference is undercitation of publications authored by women, resulting in profound negative effects on academic visibility and career advancement. This inequality has been documented in fields where author gender distributions are strongly skewed towards men (astronomy, physics, neuroscience). By investigating citation practices in a field that has traditionally been more accessible to female scientists (speech–language pathology, SLP), we demonstrate that gendered citation practices are mediated by author gender distribution in specific fields, rather than being a universal pattern. Specifically, our results revealed a citation pattern in SLP that overall tends to favor female authors, persists after controlling for potential confounding factors and, is particularly strong when female authors are citing publications involving female first and senior author teams. Our results suggest that the implementation of effective measures to increase the number and influence of underrepresented individuals in specific fields of science may contribute to mitigate downstream disadvantages for career advancement. However, future research in fields with different author gender distributions and consideration of additional mediating factors is required to establish a potential causal link between field specific authorship patterns and gendered citation inequality.
  • OPEN ACCESS
    Poor mental health negatively impacts farmers personally, interpersonally, cognitively, and professionally
    FACETS • Vol. 9 • pp. 1 - 16
    Farmers globally face significant occupational stressors and are reported to experience high levels of depression, anxiety, burnout, suicide ideation, and suicide. While the impacts of high stress and poor mental health have been well-studied in the general population, and to some extent, in specific occupations, the impacts on farmers are understudied. The objective here was to explore the lived experience of high stress and (or) poor mental health in Canadian farmers, including the perceived impacts. Using a phenomenological approach within a constructivist paradigm, we conducted 75 one-on-one research interviews with farmers and people who work closely with farmers, in Ontario, Canada, between July 2017 and May 2018. We analysed the data via thematic analyses and identified four major themes. Participants described myriad negative impacts of farmers’ high stress and (or) poor mental health: (1) personally, (2) interpersonally, and (3) cognitively, which ultimately negatively impacted them (4) professionally, including consequences for productivity, animals, and farm success. The data described far-reaching, interconnected impacts of high stress and poor mental health on participants, the people and animals in their lives, and most aspects of their farming operations, financial viability, and success. Farmer stress, mental health, and well-being are important considerations in promoting sustainable, successful agriculture.