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  • OPEN ACCESS
    Levels of brain-derived neurotrophic factor in patients with fibromyalgia and chronic low back pain: Results of an aquatic physical therapy protocol
    FACETS • Vol. 3 • No. 1 • pp. 12 - 21
    Objectives: This work aims to assess changes in brain-derived neurotrophic factor (BDNF) levels in women after the practice of a specific short duration 10-session aquatic physical therapy protocol in patients with fibromyalgia (FB). Methods: Case–control study. Thirteen women diagnosed with FB and 11 controls with the same age group, 35–55 years. Patients were evaluated according to the visual analog scale of pain and the fibromyalgia impact questionnaire (FIQ). All were subjected to a short protocol totaling 10 sessions of 40 min twice a week for five weeks. Heart rate and pain were monitored. BDNF levels were measured using enzyme immunoassay. Results: A statistically significant increase in BDNF values was noted in patients with FB between the pre- and post-10th session assessments (mean of 35.52–41.96; p = 0.041). Conclusion: BDNF values may present fluctuations during a short duration moderate aerobic exercise protocol, when measured and analyzed in a longitudinal design. Further studies with a more frequent BDNF evaluation could help in understanding its behavior more accurately and are warranted.
  • OPEN ACCESS
    Why colour is complex: Evidence that bees perceive neither brightness nor green contrast in colour signal processing
    FACETS • Vol. 3 • No. 1 • pp. 800 - 817
    Honey bees (Apis mellifera Linnaeus, 1758) potentially rely on a variety of visual cues when searching for flowers in the environment. Both chromatic and achromatic (brightness) components of flower signals have typically been considered simultaneously to understand how flower colours have evolved. However, it is unclear whether honey bees actually use brightness information in their colour perception. We investigated whether free-flying honey bees can process brightness cues in achromatic stimuli when presented at a large visual angle of 28° to ensure colour processing. We found that green contrast (modulation of the green receptor against the background) and brightness contrast (modulation of all three receptors against the background) did not have a significant effect on the proportion of correct choices made by bees, indicating that they did not appear to use brightness cues in a colour processing context. Our findings also reveal that, even at a small visual angle, honeybees do not reliably process single targets solely based on achromatic information, at least considering values up to 60% modulation of brightness. We discuss these findings in relation to proposed models of bee colour processing. Therefore, caution should be taken when interpreting elemental components of complex flower colours as perceived by different animals.
  • OPEN ACCESS
    Pyrogenic and neuroinflammatory properties of zymosan and its potential as an alternative to live yeast in antipyretic drug testing
    FACETS • Vol. 4 • No. 1 • pp. 162 - 182
    Zymosan, an immunogenic cell wall extract of Saccharomyces cerevisiae has potential for use as an experimental pyrogen. However, the short-lived sickness responses noted with intraperitoneal and intra-articular administration of zymosan limits investigations on the long-term effectiveness of antipyretic drugs. Thus, there remains a need to establish an alternative route of zymosan administration that could induce long-lived fevers and inflammation. We injected male Sprague Dawley rats (250–300 g) subcutaneously with zymosan (30 or 300 mg/kg) or saline; n = 7–8. We measured core body temperature, cage activity, food intake and body mass for 24 h after injection. Blood and brain samples were collected at 2, 8, and 18 h after injection. Zymosan (300 mg/kg) induced fever, lethargy, and anorexia, which lasted for 24 h. Zymosan-induced sickness responses were accompanied by increased blood plasma levels of interleukin (IL)-6 and tumor necrosis factor (TNF)-α; activation of inflammatory transcription factors (nuclear factor (NF) for IL-6, signal transducer and activator of transcription (STAT)-3, and NF-κB) in the hypothalamus and circumventricular organs; and increased hypothalamic mRNA expression of TNF-α, IL-1β, and IL-6 and rate-limiting enzymes for prostaglandin synthesis. Our results confirm the suitability of subcutaneous administration of zymosan for screening antipyretic and anti-inflammatory drugs in rats.
  • OPEN ACCESS
    Relaxin peptides reduce cellular damage in cultured brain slices exposed to transient oxygen–glucose deprivation: an effect mediated by nitric oxide
    FACETS • Vol. 6 • pp. 118 - 130
    The effect of treatment with human relaxins on cell death was studied in oxygen- and glucose-deprived brain slices. In addition, involvement of nitric oxide and the relaxin receptor, RXFP3, was studied. Brain slices (n = 12–18/group) were cultured under standard conditions for two weeks and then exposed to: (i) an oxygenated balanced salt solution, (ii) a deoxygenated, glucose-free balanced salt solution (OGD media), or (iii) OGD media containing 10−7 mol/L H2 relaxin, 10−7 mol/L H2 relaxin with 50 μmol/L L-NIL, 10−7 mol/L H3 relaxin, or 10−7 mol/L H3 relaxin with 50 μmol/L L-NIL. Cell death was assessed using propidium iodide fluorescence. In a separate experiment, 10−5 mol/L R3 B1-22R (an antagonist of RXFP3) was added to both H2 and H3 relaxin treatments. H2 and H3 relaxin treatment reduced cell damage or death in OGD slices and L-NIL partially attenuated the effect of H3 relaxin. Antagonism of RXFP3 blocked the effect of H3 but not H2 relaxin. These data increase our understanding of the role of relaxin ligands and their receptors in protecting tissues throughout the body from ischemia and reperfusion injury.
  • OPEN ACCESS
    Lower extremity muscle strength reference values for young Saudi male adults aged 21 to 23 years and their correlation with anthropometric parameters and balance
    FACETS • Vol. 7 • pp. 98 - 109
    Normative reference values for muscle strength are needed for muscle strength assessment and estimation of prognosis in lower extremity related neuromuscular disorders, as muscle strength influenced by anthropometric parameters and muscle strength itself affects balance. Normative reference values for muscle strength in the Saudi Arabian population is lacking in the literature. Hence, the current study aimed to establish normative reference values for lower extremity muscle strength and to correlate these values with anthropometric parameters and balance. Lower extremity muscle strength and balance were assessed by baseline hand-held dynamometer and by forward, lateral, and oblique direction reach tests in 421 young male adults between 21 and 23 years of age. The mean and standard deviation of lower extremity strength ranged from 43.83 ± 16.92 lb to 62.07 ± 10.74 lb. Body weight, body mass index, and oblique and lateral reach distances were correlated with some knee and ankle muscle strength values. Body weight, body mass index, and balance showed significant effect on lower extremity muscle strength. Furthermore, decreased muscle strength may impair balance; the current clinical practice should evaluate body weight, body mass index, and muscle strength during the assessment process.
  • OPEN ACCESS
    Gender-based citation differences in speech–language pathology
    FACETS • Vol. 9 • pp. 1 - 8
    Gender inequalities are well documented in science and typically favor male scientists. A particularly pervasive gender difference is undercitation of publications authored by women, resulting in profound negative effects on academic visibility and career advancement. This inequality has been documented in fields where author gender distributions are strongly skewed towards men (astronomy, physics, neuroscience). By investigating citation practices in a field that has traditionally been more accessible to female scientists (speech–language pathology, SLP), we demonstrate that gendered citation practices are mediated by author gender distribution in specific fields, rather than being a universal pattern. Specifically, our results revealed a citation pattern in SLP that overall tends to favor female authors, persists after controlling for potential confounding factors and, is particularly strong when female authors are citing publications involving female first and senior author teams. Our results suggest that the implementation of effective measures to increase the number and influence of underrepresented individuals in specific fields of science may contribute to mitigate downstream disadvantages for career advancement. However, future research in fields with different author gender distributions and consideration of additional mediating factors is required to establish a potential causal link between field specific authorship patterns and gendered citation inequality.